Meningococcal disease is a serious illness, caused by bacteria. It is a leading cause of bacterial meningitis in children 2-18 years old in the United States.

Meningitis is an infection of fluid surrounding the brain and the spinal cord. Meningococcal disease also causes blood infections.

About 2,600 people get meningococcal disease each year in the U.S. 10-15% of these people die, in spite of treatment with antibiotics. Of those who live, another 11-19% lose their arms or legs, become deaf, have problems with their nervous systems, become mentally retarded, or suffer seizures or strokes.

Anyone can get meningococcal disease. But it is most common in infants less than one year of age and people with certain medical conditions, such as lack of a spleen. College freshmen who live in dormitories have an increased risk of getting meningococcal disease.

Meningococcal infections can be treated with drugs such as penicillin. Still, about 1 out of every ten people who get the disease dies from it, and many others are affected for life. This is why preventing the disease through use of meningococcal vaccine is important for people at highest risk.

Meningococcal Vaccine 

Two meningococcal vaccines are available in the U.S.:

  • Meningococcal polysaccharide vaccine (MPSV4) has been available since the 1970s.
  • Meningococcal conjugate vaccine (MCV4) was licensed in 2005.

Both vaccines can prevent 4 types of meningococcal disease, including 2 of the 3 types most common in the United States and a type that causes epidemics in Africa. Meningococcal vaccines cannot prevent all types of the disease. But they do protect many people who might become sick if they didn’t get the vaccine.

Both vaccines work well, and protect about 90% of those who get it. MCV4 is expected to give better, longer-lasting protection. MCV4 should also be better at preventing the disease from spreading from person to person.

Who should get meningococcal vaccine, and when? 

MCV4 is recommended for all children at their routine preadolescent visit (11-12 years of age). For those who have never gotten MCV4 previously, a dose is recommended at high school entry.

Other adolescents who want to decrease their risk of meningococcal disease can also get the vaccine.

Meningococcal vaccine is also recommended for other people at increased risk for meningococcal disease:

  • College freshmen living in dormitories
  • Microbiologists who are routinely exposed to meningococcal bacteria
  • U.S. military recruits
  • Anyone traveling to, or living in, a part of the world where meningococcal disease is common, such as parts of Africa
  • Anyone who has a damaged spleen, or whose spleen has been removed
  • Anyone who has terminal complement component deficiency (an immune system disorder)
  • People who might have been exposed to meningitis during an outbreak

MCV4 is the preferred vaccine for people 11-55 years of age in these risk groups, but MPSV4 can be used if MCV4 is not available. MPSV4 should be used for children 2-10 years old and adults over 55, who are at risk.

How Many Doses?

People 2 years of age and older should get 1 dose. (Sometimes an additional dose is recommended for people who remain at high risk. Ask your provider.)

MPSV4 may be recommended for children 3 months to 2 years of age under special circumstances. These children should get 2 doses, 3 months apart.

Some people should not get meningococcal vaccine, or should wait 

  • Anyone who has ever had a severe (life-threatening) allergic reaction to a previous dose of either meningococcal vaccine should not get another dose.
  • Anyone who has a severe (life threatening) allergy to any vaccine component should not get the vaccine. Tell your doctor if you have any severe allergies.
  • Anyone who is moderately or severely ill at the time the shot is scheduled should probably wait until they recover. Ask your doctor or nurse. People with a mild illness can usually get the vaccine.
  • Anyone who has ever had Guillain-Barré Syndrome should talk with their doctor before getting MCV4.
  • Meningococcal vaccines may be given to pregnant women. However, MCV4 is a new vaccine and has not been studied in pregnant women as much as MPSV4 has. It should be used only if clearly needed.

Meningococcal vaccines may be given at the same time as other vaccines.

What are the risks from meningococcal vaccines? 

A vaccine, like any medicine, could possibly cause serious problems, such as severe allergic reactions. The risk of meningococcal vaccine causing serious harm, or death, is extremely small.

Mild problems

Up to about half of people who get meningococcal vaccines have mild side effects, such as redness or pain where the shot was given.

If these problems occur, they usually last for 1 or 2 days. They are more common after MCV4 than after MPSV4.

A small percentage of people who receive the vaccine develop a fever.

Severe problems 

  • Serious allergic reactions, within a few minutes to a few hours of the shot, are very rare.
  • A few cases of Guillain-Barré Syndrome, a serious nervous system disorder, have been reported among people who got MCV4. There is not enough evidence yet to tell whether they were caused by the vaccine. This is being investigated by health officials.

What if there is a severe or moderate reaction? 

What should I look for? 

Any unusual condition, such as a high fever or behavior changes. Signs of a serious allergic reaction can include difficulty breathing, hoarseness or wheezing, hives, paleness, weakness, a fast heart beat or dizziness.

What should I do? 

  • Call a doctor, or get the child to a doctor right away.
  • Tell your doctor what happened, the date and time it happened, and when the vaccination was given.
  • Ask your doctor, nurse, or health department to report the reaction by filing a Vaccine Adverse Event Reporting System form.

Or you can file this report through the VAERS web site at or by calling: 1-800-822-7967. VAERS does not provide medical advice.

The National Vaccine Injury Compensation Program

In the rare event that you or your child has a serious reaction to a vaccine, a federal program has been created to help pay for the care of those who have been harmed. For details about the National Vaccine Injury Compensation Program, call: 1-800-338-2382, or visit them online.

What Will I Need to do Before My Child Can Receive the Meningococcal Vaccine? 

On the day of your child’s appointment, you will be asked to read information from the Centers for Disease Control and Prevention (CDC) regarding this vaccination. Information from that statement has been reproduced in this article.

  • To review the Vaccine Information Statement prior to your appointment, click here.
  • To view a full listing of the Vaccine Information Statements available through the CDC, click here.

Click here for more information on Meningococcal

This Vaccine Information Statement courtesy of:
U.S. Department of Health and Human Services
Centers for Disease Control and Prevention
National Immunization Program

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